Optic nerve head structure in glaucoma: Astrocytes as mediators of axonal damage
نویسندگان
چکیده
منابع مشابه
Optic Nerve Head Blood Flow in Glaucoma
These days it is commonly accepted that multiple factors are involved in the etiology of glaucoma. Although many studies have demonstrated that the major risk factor for glaucoma is an increase in intraocular pressure (IOP), some studies, including epidemiologic studies, have suggested an association between glaucoma, especially primary open-angle glaucoma (POAG) and normal-tension glaucoma (NT...
متن کاملThe optic nerve head in myocilin glaucoma.
PURPOSE Approximately 1 in 30 unselected patients with open-angle glaucoma (OAG) have a mutation in the myocilin gene. The purpose of this study was to describe the morphologic features of the optic nerve head (ONH) in myocilin glaucoma. METHODS A case-control design was adopted. Sixty-six patients heterozygous for a range of myocilin mutation (cases) were matched in disease severity to 105 p...
متن کاملGap junctions between optic nerve head astrocytes
From The Wilmer Institute, W. K. Kellogg Foundation Laboratories, The Johns Hopkins University School of Medicine, Baltimore, Md. This investigation was conducted under a Post-Doctoral Research Fellowship supported by a Bob Hope-Fight For Sight Award of the National Council to Combat Blindness, Inc., New York, N. Y. Submitted for publication Nov. 30, 1976. Reprint requests: Dr. Roger C. Wales, ...
متن کاملThe optic nerve head in glaucoma
The ONH can be examined using a direct ophthalmoscope, an indirect ophthalmoscope, or a posterior pole lens with a slit lamp. Many types of health professional can assess the ONH accurately after having appropriate training. Dilating the pupil makes this easier and will improve the accuracy of the examination, regardless of which instrument is used. Where the equipment is available, more sophis...
متن کاملGap junctions between optic nerve head astrocytes.
Astrocytes of the primate and human optic nerve head are joined to each other by the gap junction type of intercellular membrane specialization. Although the precise function of these contacts is not fully determined, they may serve such diverse roles as adhesive bonding and intercellular electrical and chemical coupling.
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ژورنال
عنوان ژورنال: Eye
سال: 2000
ISSN: 0950-222X,1476-5454
DOI: 10.1038/eye.2000.128